| Autor: |
Kolik LG, Zhukov VN, Seredenin SB |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2007 Mar-Apr; Vol. 70 (2), pp. 8-11. |
| Abstrakt: |
The antinociceptive and anxiolytic properties of the new drug GB-115 (0.0125-4 mg/kg, i.p.), which is a short peptide antagonist of CCK2-receptors, have been studied in rats and mice using thermal models of nociception and the standard "elevated plus-maze" (EPM) test for measuring anxiety. It s established that GB-115 (4 mg/kg) significantly increases the response latency in naloxone-independent manner in the "hot plate" test in mice and produced a moderate naloxone-reversible analgesic effect in the "tail flick" test in mice. The blocking of opioid receptors by naloxone does not influence the anxiolytic effects of GB-115 (0.025 and 4 mg/kg) in the EPM test on rats. It has been suggested that GB-115 produced anxiolytic acting on CCK2-receptors, and its role in the control of pain perception is manifested through the interaction with opioidergic mechanisms on a spinal level rather than with non-opioid mechanisms on a supraspinal level. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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