| Autor: |
Sheleg SV; Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Peloponese JM, Chi YH, Li Y, Eckhaus M, Jeang KT |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of virology [J Virol] 2007 Aug; Vol. 81 (15), pp. 7894-901. Date of Electronic Publication: 2007 May 16. |
| DOI: |
10.1128/JVI.00555-07 |
| Abstrakt: |
Aneuploidy is frequent in cancers. Recently it was found that pituitary tumor transforming gene (PTTG; also called Pds1p or securin) is overexpressed in many different tumors. Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that primarily infects CD4+ T lymphocytes and causes adult T-cell leukemia. Here, we report that overexpression of human PTTG cooperated with the HTLV-I Tax oncoprotein in cellular transformation. Coexpression of Tax and PTTG enhanced chromosomal instability and neoplastic changes to levels greater than overexpression of either factor singularly. Cells that overexpressed both PTTG and Tax induced tumors more robustly in nude mice than cells that expressed either PTTG alone or Tax alone. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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