The psychomodulatory action of subpyrogenic doses of interleukin-1beta in conditions of chronic administration to rats.

Autor: Sokolova ES; State Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, 12 Academician Pavlov Street, 197376, St. Petersburg, Russia. v/ioudyno@mail.ru, Lyudyno VI, Simbirtsev AS, Klimenko VM
Jazyk: angličtina
Zdroj: Neuroscience and behavioral physiology [Neurosci Behav Physiol] 2007 Jun; Vol. 37 (5), pp. 499-504.
DOI: 10.1007/s11055-007-0042-3
Abstrakt: The effects of interleukin-1beta at low, subpyrogenic doses on behavior were studied in rats. Signs of increased anxiety were evident by day 5 of treatment courses. These results provide evidence supporting the role of proinflammatory cytokines in the pathogenesis of emotional disorders.
Databáze: MEDLINE