| Autor: |
van Berkel ME; Department of Immunology, University Medical Center, Utrecht, The Netherlands. m.vanberkel@umcutrecht.nl, Schrijver EH, van Mourik A, Tesselaar K, van der Ley P, Steeghs L, Oosterwegel MA |
| Jazyk: |
angličtina |
| Zdroj: |
Vaccine [Vaccine] 2007 Jun 11; Vol. 25 (24), pp. 4681-8. Date of Electronic Publication: 2007 Apr 25. |
| DOI: |
10.1016/j.vaccine.2007.04.016 |
| Abstrakt: |
The development of novel vaccines against Neisseria meningitidis recently gained momentum by the generation of penta-acylated lpxL1 LPS which has similar adjuvant activity, but reduced endotoxic activity as compared to hexa-acylated wild type (H44/76) LPS. We investigated the costimulation requirements for the adjuvant activity of both forms of LPS by immunizing CD28-, ICOS- and B7.1/2/ICOS-deficient mice. Both ICOS and CD28 appeared essential for optimal adjuvant activity of H44/76 LPS or lpxL1 LPS. Interestingly, ICOS-mediated costimulation predominates in the adjuvant activity of lpxL1 LPS, while both ICOS and CD28 are required for H44/76 LPS adjuvant activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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