| Autor: |
Yeatman TJ; Department of Surgery, University of Texas, MD Anderson Cancer Center, Houston 77036., Risley GL, Brunson ME |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of surgery (Chicago, Ill. : 1960) [Arch Surg] 1991 Nov; Vol. 126 (11), pp. 1376-81; discussion 1381-2. |
| DOI: |
10.1001/archsurg.1991.01410350066010 |
| Abstrakt: |
The effects of dietary arginine on the growth of a murine colon tumor metastatic to the liver were examined in a model of advanced neoplastic disease. Tumor growth was influenced by arginine both in vivo and in vitro. An arginine-supplemented diet stimulated tumor growth by 55% compared with controls. Conversely, an arginine-depleted diet inhibited tumor growth by 78% compared with controls. In vitro culture of both murine and human colon tumor cells confirmed that arginine was necessary for cell growth. Flow-cytometric analysis using propidium iodide and bromodeoxyuridine suggested that colon tumor cells cultured without arginine enter a quiescent S phase and depend on arginine for further growth and cell cycle progression. The potential roles for selective dietary arginine modulation in patients with cancer with advanced disease are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
