| Autor: |
Rubin P; Department of Psychiatry, Bispebjerg Hospital, Copenhagen, Denmark., Holm S, Friberg L, Videbech P, Andersen HS, Bendsen BB, Strømsø N, Larsen JK, Lassen NA, Hemmingsen R |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of general psychiatry [Arch Gen Psychiatry] 1991 Nov; Vol. 48 (11), pp. 987-95. |
| DOI: |
10.1001/archpsyc.1991.01810350027004 |
| Abstrakt: |
To measure prefrontal and subcortical activity during a cognitive task, we examined 19 newly diagnosed schizophrenics and patients with schizophreniform psychosis. Seven healthy volunteers served as controls. The patients were drug naive or had received neuroleptics for a few days only. Cerebral blood flow distribution was depicted by single photon emission computed tomography at rest and during activation with the Wisconsin Card Sorting Test. A significant relative activation deficit in the left inferior-prefrontal region was revealed during the Wisconsin Card Sorting Test in the patient group. Furthermore, the patients had impaired striatal suppression on the left side during the cognitive task. The test performance was significantly impaired in the patients. The inability to reduce striatal activity may be due to a lack of corticostriatal feedback during prefrontal activation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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