Genotoxicity screening for N-nitroso compounds. Electrochemical and electrochemiluminescent detection of human enzyme-generated DNA damage from N-nitrosopyrrolidine.

Autor: Krishnan S; Department of Chemistry (U-60), 55 N. Eagleville Rd., University of Connecticut, Connecticut, USA., Hvastkovs EG, Bajrami B, Jansson I, Schenkman JB, Rusling JF
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2007 May 07 (17), pp. 1713-5. Date of Electronic Publication: 2007 Apr 03.
DOI: 10.1039/b703012f
Abstrakt: We report for the first time voltammetric/electrochemiluminescent sensors applied to predict genotoxicity of N-nitroso compounds bioactivated by human cytochrome P450 enzymes.
Databáze: MEDLINE