| Autor: |
Han JH; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada., Kushner SA, Yiu AP, Cole CJ, Matynia A, Brown RA, Neve RL, Guzowski JF, Silva AJ, Josselyn SA |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 2007 Apr 20; Vol. 316 (5823), pp. 457-60. |
| DOI: |
10.1126/science.1139438 |
| Abstrakt: |
Competition between neurons is necessary for refining neural circuits during development and may be important for selecting the neurons that participate in encoding memories in the adult brain. To examine neuronal competition during memory formation, we conducted experiments with mice in which we manipulated the function of CREB (adenosine 3',5'-monophosphate response element-binding protein) in subsets of neurons. Changes in CREB function influenced the probability that individual lateral amygdala neurons were recruited into a fear memory trace. Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in amemorytrace as a function of their relative CREB activity at the time of learning. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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