[Modulation of programmed death of the peripheral blood lymphocytes under chronic virus infection].

Autor: Zhukova OB, Riazantseva NV, Novitskiĭ VV, Radzivil TT, Litvinova LS, Chasovskikh NIu
Jazyk: ruština
Zdroj: Tsitologiia [Tsitologiia] 2007; Vol. 49 (1), pp. 26-31.
Abstrakt: We investigated programmed death of lymphocytes in patients with chronic infections--tick-borne encephalitis, hepatitis B and C. It has been shown that the character of disorders in realization of lymphocyte apoptosis depends on molecular features of the infectious agent. Apoptotic death of lymphocytes was elevated after incubation in vitro with dexamethazone, etopozide and in medium without serum. Receptor-dependent and mitochondrial paths of apoptotic signal conduction are preferentially modulated under chronic virus persistence.
Databáze: MEDLINE