Effects of fluvoxamine on behavioral and psychological symptoms of dementia in Alzheimer's disease: a report of three cases.

Autor: Kurita M; Kotokukai Sato Hospital, Yamagata, 960-2156, Japan. m-kurita@fmu.ac.jp, Sato T, Nishino S, Ohtomo K, Shirakawa H, Mashiko H, Niwa S, Nakahata N
Jazyk: angličtina
Zdroj: Fukushima journal of medical science [Fukushima J Med Sci] 2006 Dec; Vol. 52 (2), pp. 143-8.
DOI: 10.5387/fms.52.143
Abstrakt: Objective: To report 3 cases of severe behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) with fluvoxamine treatment and to discuss the treatment implications for use of the drug.
Case Summary: An 83-year-old woman was diagnosed with AD. Before treatment, she showed sudden irritation and excitement. Her BEHAVE-AD score was 40. She was started on fluvoxamine and quetiapine. Eight weeks later, she was friendly and thankful towards the staff. Her BEHAVE-AD score was 10. The second case was a 79-year-old woman diagnosed with AD. Before treatment, she attempted to leave our hospital and wandered and shouted throughout the day. Her BEHAVE-AD score was 42. She was started on fluvoxamine, and the dosage was gradually increased. Eight weeks later, the shouting and excitement disappeared almost completely. Her BEHAVE-AD score was 13. The third case was a 79-year-old man diagnosed with AD. Before treatment, we put him in a private, locked room because he was extremely agitated and violent because of delusions. His BEHAVE-AD score was 42. He was started on fluvoxamine and sodium valproate. Eight weeks later, the delusion became mild and did not affect his mood or behavior. His BEHAVE-AD score at this point was 4.
Discussion: Fluvoxamine was effective in controlling BPSD with AD. This finding shows that the pathophysiology of BPSD due to AD may occur because of a hyposerotonergic state in the brain.
Conclusion: These cases show that fluvoxamine appears to be effective in the control of BPSD with AD.
Databáze: MEDLINE