Walker 256 tumor growth in rats with hereditary defect of vasopressin synthesis.

Autor: Khegai II; Laboratory of Physiological Genetics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk. khegay@bionet.nsc.ru, Popova NA, Zakharova LA, Ivanova LN
Jazyk: English; Russian
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2006 Sep; Vol. 142 (3), pp. 344-6.
DOI: 10.1007/s10517-006-0362-2
Abstrakt: Stable deceleration of Walker 256 tumor growth was detected in Brattleboro rats with vasopressin synthesis defect in comparison with normal WAG rats. In contrast to continuous tumor growth typical of rats, the growth of this tumor in Brattleboro rats was negligible and was observed during the first 15-18 days after transplantation, after which the tumor regressed and disappeared. The effect was age-dependent and was more pronounced in old animals. Repeated injection of Walker 256 cells does not lead to tumor development, which attested to direct involvement of the immune system in the detected phenomenon.
Databáze: MEDLINE