Efficacy of Sulbactam, a B-lactamase Inhibitor, Combined with Ampicillin in the Therapy of Ampicillin-resistant Pneumonic Pasteurellosis in Feedlot Calves.

Autor: Bentley OE, Cummins JM
Jazyk: angličtina
Zdroj: The Canadian veterinary journal = La revue veterinaire canadienne [Can Vet J] 1987 Sep; Vol. 28 (9), pp. 591-4.
Abstrakt: Two field efficacy studies, involving a total of 80 naturally infected feedlot calves, were conducted to compare the efficacy of sulbactam-ampicillin with that of penicillin-dihydrostreptomycin in the treatment of pneumonic pasteurellosis. Cultures from pretreatment nasal swabs were predominantly ampicillin/ penicillin resistant Pasteurella haemolytica. Clinical observations revealed that cattle treated with penicillin-dihydrostreptomycin responded poorly, whereas those treated with sulbactam-ampicillin responded promptly. Twenty-four hours after initiation of treatment, mean body temperatures of the calves in the sulbactam-ampicillin groups had decreased by 2.1 degrees C, whereas, in the penicillin-dihydrostreptomycin calves there was little change. The difference between the two treatments was statistically significant (P
Databáze: MEDLINE