| Autor: |
Lu M; Department of Chemistry, New York University, New York 10003., Guo Q, Krishnan B, Golik J, Rosenberg IE, Doyle TW, Kallenbach NR |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 1991 Oct; Vol. 9 (2), pp. 285-98. |
| DOI: |
10.1080/07391102.1991.10507913 |
| Abstrakt: |
The esperamicins are members of a class of potent antitumor antibiotics that contain stained diacetylenic ring systems capable of forming DNA-cleaving diradicals upon reaction with thiols. Here we show that the diacetylenic ring core itself determines the sequence specificity for scission of duplex DNA): esperamicin A1, and three products of hydrolysis of the glycon, esperamicins C, D, and E, are found to retain a common sequence preference. The sugar residues exert a strong influence on the cleavage efficiency, presumably by interacting nonspecifically with DNA. The presence of a branch in the DNA is found locally to inhibit scission by esperamicins, and this effect is shown to be due to the core also. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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