Effect of prolonged emotional and pain stress on the content of methylcytosine-binding protein MeCP2 in nuclei of hippocampal neurons in rats with different excitability of the nervous system.

Autor: Dyuzhikova NA; Laboratory for Genetics of Higher Nervous Activity, Laboratory of Neurogenetics, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. dyuzhikova@kolt.infran.ru, Savenko YN, Sokolova NE, Savvateeva-Popova EV, Vaido AI
Jazyk: English; Russian
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2006 Aug; Vol. 142 (2), pp. 239-41.
DOI: 10.1007/s10517-006-0337-3
Abstrakt: In rats with low excitability threshold of the nervous system demonstrating significant and persistent behavioral disorders under stress conditions, the content of methylcytosine-binding protein MeCP2 in neuronal nuclei of hippocampal field CA3 decreased over 2 weeks after long-term emotional and pain stress. It was hypothesized that protein MeCP2 triggers epigenetic changes in DNA that underlie "stress memory".
Databáze: MEDLINE
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