| Autor: |
Ihedioha JI; Departments of Veterinary Pathology and Microbiology, University of Nigeria Nsukka, PO Box 3236, Nsukka 410001, Nigeria. jiiferh@yahoo.com, Ochiogu IS, Ihedioha TE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of comparative pathology [J Comp Pathol] 2007 Feb-Apr; Vol. 136 (2-3), pp. 206-11. Date of Electronic Publication: 2007 Mar 26. |
| DOI: |
10.1016/j.jcpa.2007.01.003 |
| Abstrakt: |
This study investigated the effects of co-administration of Na-EDTA and diminazene aceturate (DA) on the level of parasitaemia (LOP), parasite clearance, packed cell volume (PCV) and post-infection survival time (PIST) in mice infected with DA-resistant Trypanosoma brucei. Five groups of 10 mice were treated as follows: infected and treated with Na-EDTA+DA; infected and treated with DA alone; infected and treated with Na-EDTA alone; infected-untreated; and uninfected-untreated. The co-administration of Na-EDTA and DA led to reduced LOP and improvements in PCV (P<0.05), as compared with treatment with DA alone. Mice treated with Na-EDTA+DA had a marginally (P>0.05) higher PIST than did mice treated with DA alone. Comparison of the group given Na-EDTA alone with the infected-untreated group showed that the former group had a significantly lower (P<0.01) LOP, improved PCV (P<0.05) and higher (P<0.01) PIST. It was concluded that the co-administration of Na-EDTA and DA led to a slight potentiation of DA in the treatment of mice infected with DA-resistant T. brucei, and that the administration of Na-EDTA alone significantly enhanced the resistance of the infected mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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