MRI patterns in prolonged low response states following traumatic brain injury in children and adolescents.

Autor:	Patrick PD; Department of Pediatrics, Kluge Children's Rehabilitation Center and Research Institute, University of Virginia, Charlottesville, VA 22901, USA. pdp2n@virginia.edu, Mabry JL, Gurka MJ, Buck ML, Boatwright E, Blackman JA
Jazyk:	angličtina
Zdroj:	Brain injury [Brain Inj] 2007 Jan; Vol. 21 (1), pp. 63-8.
DOI:	10.1080/02699050601111401
Abstrakt:	Objectives: To explore the relationship between location and pattern of brain injury identified on MRI and prolonged low response state in children post-traumatic brain injury (TBI). Methods: This observational study compared 15 children who spontaneously recovered within 30 days post-TBI to 17 who remained in a prolonged low response state. Results: 92.9% of children with brain stem injury were in the low response group. The predicted probability was 0.81 for brain stem injury alone, increasing to 0.95 with a regional pattern of injury to the brain stem, basal ganglia, and thalamus. Conclusions: Low response state in children post-TBI is strongly correlated with two distinctive regions of injury: the brain stem alone, and an injury pattern to the brain stem, basal ganglia, and thalamus. This study demonstrates the need for large-scale clinical studies using MRI as a tool for outcome assessment in children and adolescents following severe TBI.
Databáze:	MEDLINE
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