| Autor: |
Rodriguez M; Department of Neurology, Mayo Medical School, Rochester, MN., Lindsley MD |
| Jazyk: |
angličtina |
| Zdroj: |
Neurology [Neurology] 1992 Feb; Vol. 42 (2), pp. 348-57. |
| DOI: |
10.1212/wnl.42.2.348 |
| Abstrakt: |
Immunosuppression using cyclophosphamide or anti-T cell monoclonal antibodies (mAbs) directed at CD4 or CD8 promoted remyelination of CNS axons in the spinal cords of mice infected chronically with Theiler's virus. Treatment with a mAb directed at class II major histocompatibility gene products did not increase the extent of CNS remyelination. Following immunosuppressive treatment, quantitative morphometry revealed a five- to sevenfold increase in new myelin synthesis. Proliferating nervous system cells were identified at the edges of remyelinated lesions by their incorporation of [3H]thymidine. CNS remyelination occurred in mice depleted of selected subsets of T lymphocytes despite the local persistence of viral antigen. These findings indicate that CNS remyelination occurs as a normal consequence of primary myelin injury, but factors associated with immune T cells somehow impair remyelination. Interference with the function of immune T cells enhances CNS remyelination by oligodendrocytes. Similar depletion of immune T cells may allow for enhanced remyelination in the CNS of patients with chronic multiple sclerosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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