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Morphometric study of placental villi and vessels in women with mild hyperglycemia or gestational or overt diabetes.

Autor: Calderon IM; Diabetes and Pregnancy Service, Department of Gynecology & Obstetrics of Botucatu Medical School, Unesp, São Paulo, Brazil. calderon@fmb.unesp.br, Damasceno DC, Amorin RL, Costa RA, Brasil MA, Rudge MV
Jazyk: angličtina
Zdroj: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2007 Oct; Vol. 78 (1), pp. 65-71. Date of Electronic Publication: 2007 Mar 13.
DOI: 10.1016/j.diabres.2007.01.023
Abstrakt: In this study, morphometric measures of placental terminal villi and villous vessels were compared in overt, as well as gestational diabetes mellitus, and mild hyperglycemia diagnosed by oral 100 g glucose tolerance test (100 g-OGTT) and glucose profile (GP). At delivery (gestational age> or =34 weeks) a total of 207 placentas were assigned to a control group (n=56) or to one of three groups complicated by mild hyperglycemia (n=51), gestational diabetes (n=59) and overt diabetes (n=41). Placenta samples were randomly selected for blind morphometric assessment with an image analyser. Morphometric measures obtained included area and number of terminal villi and their respective villous vessels. Statistical analyses were performed using the chi-square test, ANOVA and stepwise regression (p< or =0.05). Glycemic means were 86.2 mg/dL in controls, 98.9 mg/dL in mild hyperglycemia, 114.1 mg/dL in gestational diabetes and 122.1 mg/dL in overt diabetes. Our results show that abnormal maternal glycemic levels may change the placental morphometric characteristics related to materno-fetal exchanges.
Databáze: MEDLINE
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