| Autor: |
Yole DS; Institute of Primate Research, Karen, Nairobi, Kenya. dsyole@ipr.or.ke, Gikuru SK, Wango EO, Kithome K, Kiarie S, Limo M |
| Jazyk: |
angličtina |
| Zdroj: |
African journal of health sciences [Afr J Health Sci] 2006 Jan-Jun; Vol. 13 (1-2), pp. 47-54. |
| Abstrakt: |
Intensity of human schistosomiasis infection increases with age, a peak being attained at early puberty. Hormones could be involved in the age-related changes in susceptibility to schistosomiasis. Male BALB / c mice were infected with Schistosoma mansoni either before or after puberty and worm numbers, cellular immune responses, hormonal levels and pathology analysed. Pre-puberty infected mice had a significantly higher number of adult worms (p < 0.05), more severe granulomas, higher mortality rate and higher proliferative responses as compared to post-puberty infected mice. Levels of the hormones were lower in the pre-puberty infected mice as compared to the post-puberty group early in the infection. Plasma levels of testosterone and luteinizing hormones decreased significantly (p < 0.05) in infected mice when compared to controls. Susceptibility to S. mansoni in male BALB / c mice seems to be influenced by levels of testosterone and luteinizing hormone at infection. Albeit, an infection with S. mansoni seems to lower the hormonal levels. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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