| Autor: |
Verschuuren JJ; Department of Immunology, University of Limburg, Maastricht, Netherlands., Graus YM, Theunissen RO, Yamamoto T, Vincent A, van Breda Vriesman PJ, De Baets MH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neuroimmunology [J Neuroimmunol] 1992 Feb; Vol. 36 (2-3), pp. 117-25. |
| DOI: |
10.1016/0165-5728(92)90043-k |
| Abstrakt: |
In experimental autoimmune myasthenia gravis anti-rat nicotinic acetylcholine receptor (AChR) antibody titers correlated significantly with the AChR-antibody complexes found in muscle. It was shown that at least a large part of the AChR-antibody complexes are formed in vitro, which can be prevented by washing of the muscle homogenate. Using a modified assay, no differences in AChR-antibody complexes could be detected between rats with and without symptoms of experimental autoimmune myasthenia gravis. Also no difference in AChR loss nor in inhibition of alpha-bungarotoxin binding to AChR was found between these groups of rats. However, a significant difference in the reduction of AChR function was found, using an assay measuring agonist-induced 22Na+ flux into the TE671 cell line. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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