Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast.

Autor: Aguiar Bujanda D; Servicio de Oncología Médica, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain. dagubuj@gobiernodecanarias.org, Rivero Vera JC, Cabrera Suárez MA, Aguiar Morales J, Christol R, Bohn Sarmiento U, Domínguez Cabrera C, Le Bouc Y
Jazyk: angličtina
Zdroj: The breast journal [Breast J] 2007 Mar-Apr; Vol. 13 (2), pp. 189-91.
DOI: 10.1111/j.1524-4741.2007.00398.x
Abstrakt: Nonislet cell tumor hypoglycemia (NICTH) is uncommon, and has been related to the production of insulin-like growth factor II or its high-molecular-weight precursor (big IGF-II) by the tumor. Cases of NICTH have been related to different tumors, mainly sarcomas. However, only three cases secondary to a phyllodes tumor of the breast (PTB) have been previously reported. We present the clinical course of a woman with a giant PTB, who developed an irreversible hypoglycemic coma secondary to big IGF-II production by the tumor. A brief review of the literature and possible mechanisms of this infrequent condition are also commented.
Databáze: MEDLINE