| Autor: |
Monovich L; Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA. lauren.monovich@novartis.com, Mugrage B, Quadros E, Toscano K, Tommasi R, LaVoie S, Liu E, Du Z, LaSala D, Boyar W, Steed P |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Apr 15; Vol. 17 (8), pp. 2310-1. Date of Electronic Publication: 2007 Jan 25. |
| DOI: |
10.1016/j.bmcl.2007.01.059 |
| Abstrakt: |
Halopemide, which was identified by HTS to inhibit phospholipase D2 (PLD2), provided the basis for an exploratory effort to identify potent inhibitors of PLD2 for use as inflammatory mediators. Parallel synthesis and purification were utilized to rapidly identify orally available amide analogs derived from indole 2-carboxylic acids with superior potency versus PLD2. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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