| Autor: |
Aksenova MG, Burd SG, Kachalin EIu, Avakian GN, Badalian OL, Savenkov AA, Tertyshnik OIu, Dorofeeva MIu, Belousova ED, Gusev EI |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2007; Vol. 107 (1), pp. 42-5. |
| Abstrakt: |
To search for association between the 163G>A polymorphism of the fatty acid binding protein 2 (FABP2) gene and intracellular transport of the valproic acid in the small intestines, 168 patients with different forms of epilepsy, aged from 1 to 89 years, and different illness duration have been studied. The patients received valproates (127 patients) and topiramate (41 patients) as a monotherapy. It has been shown that the 163G>A (Ala54Thr) polymorphism exerts an influence on effective dose of the valproic acid but not of topiramate. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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