Platelet-activating factor acetylhydrolase in human seminal plasma.
| Autor: | Letendre ED; University of Montreal, Maisonneuve-Rosemont Hospital Research Center, Quebec, Canada., Miron P, Roberts KD, Langlais J |
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| Jazyk: | angličtina |
| Zdroj: | Fertility and sterility [Fertil Steril] 1992 Jan; Vol. 57 (1), pp. 193-8. |
| Abstrakt: | Objective: To search for the presence of platelet-activating factor (PAF) acetylhydrolase activity in human seminal plasma. Design: Experimental. Setting: Reproductive laboratory in a university-affiliated hospital research center. Participants: Human male volunteers were selected on the basis of apparent normal health. Results: Human seminal plasma contained significant levels of PAF-acetylhydrolase activity. Enzymatic hydrolysis of PAF displayed typical kinetics and was a calcium-independent process. Platelet-activating factor acetylhydrolase in seminal plasma was associated with a very high-density lipoprotein fraction. Enzymatic activity was independent of sperm count and motility. Conclusion: Human seminal plasma contains significant levels of PAF acetylhydrolase. This enzyme may be an important factor in the regulation of PAF concentration and activity. |
| Databáze: | MEDLINE |
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