| Autor: |
Kurgaliuk NN, Tkachenko GM |
| Jazyk: |
ruština |
| Zdroj: |
Biomeditsinskaia khimiia [Biomed Khim] 2006 Nov-Dec; Vol. 52 (6), pp. 556-67. |
| Abstrakt: |
The effects of the activator of ATP-sensitive potassium channels (K(ATP)) pinacidil (0.06 mg/kg) and the blocker of these channels glibenclamide (1 mg/kg) were investigated using liver and heart mitochondria isolated from rats exhibiting high (HR) or low-resistance (LR) to hypoxia. The animals were subjected to emotional stress. Stress caused activation of mitochondrial succinate oxidation, the decrease of efficiency of alpha-ketoglutarate oxidation and intensification of lipid peroxidation (LPO). These changes were more pronounced in the LR-animals. Administration of pinacidil protected mitochondria under conditions of stress, of whereas glibenclamide abolished these changes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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