Photodynamic efficacy of topical application of chlorin e6--polyvinyl pyrrolidone complex in tumor-bearing rats.

Autor:	Istoin YP; N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Ministry of Health, Minsk, Belarus. istomin06@mail.ru, Laptsevich TP, Bizyuk SA, Alexandrova EN
Jazyk:	angličtina
Zdroj:	Experimental oncology [Exp Oncol] 2006 Dec; Vol. 28 (4), pp. 299-302.
Abstrakt:	Aim: To evaluate the antitumor efficacy of photodynamic therapy with ointment form of chlorin e6--polyvinyl pyrrolidone complex. Methods: 2 or 5% chlorin e6 ointment was applied on the surface of rat SM-1 tumor for 15 min-5 h, and then tumors were scored for photosensitizer accumulation and tissue damage induced by laser irradiation. Results: Selectivity of chlorin e6 accumulation in tumor tissues considerably increases when photosensitizer was applied topically compared with intravenous administration. Antitumor efficacy of photodynamic therapy using topical application of chlorin e6--polyvinyl pyrrolidone complex is just as high as upon intravenous administration of the preparation. Conclusion: The level of tissue accumulation of chlorin e6--polyvinyl pyrrolidone complex administered in ointment form allows to carry out fluorescence diagnosis and PDT of superficially localized malignant tumors.
Databáze:	MEDLINE
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