Examining predictive models of HRQOL in a population-based, multiethnic sample of women with breast carcinoma.
| Autor: | Ashing-Giwa KT; Center of Community Alliance for Research and Education (CCARE), Division of Population Sciences, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, USA. kashing@coh.org, Tejero JS, Kim J, Padilla GV, Hellemann G |
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| Jazyk: | angličtina |
| Zdroj: | Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2007 Apr; Vol. 16 (3), pp. 413-28. Date of Electronic Publication: 2007 Feb 06. |
| DOI: | 10.1007/s11136-006-9138-4 |
| Abstrakt: | Background: This study examined health related quality of life (HRQOL) and its predictors among African-, Asian-, Latina-, and European American breast cancer survivors (BCS) using a socio-ecologically and culturally contextual theoretical model of HRQOL. Methods: We employed a case-control, cross sectional design with a population-based sample from the California Cancer Registry. Descriptive, bivariate, and multivariate regression analyses were conducted. Results: The sample included 703 BCS: 135 (19%) African-, 206 (29%) Asian-, 183 (26%) Latina-, and 179 (26%) European Americans. Latinas reported the lowest HRQOL (p < 0.0001). The final regression model explained 70% of variance in HRQOL. Years since diagnosis, number of comorbidities, role limitation, emotional wellbeing, quality of doctor-patient relationship, social support, and life stress are significant HRQOL determinants. Exploratory regression analyses indicate ethnic differences in significant predictors for HRQOL. Conclusions: HRQOL among this multiethnic sample ranged from fair to good. Bivariate analysis suggests that ethnic differences in HRQOL exist. However, regression analyses demonstrated that socio-ecological factors in conjunction with medical characteristics are more salient to HRQOL outcomes, and that ethnic group membership may be a proxy for socio-ecological context. Furthermore, the influence of ethnicity, culture, and social-ecology are complex; research with large, population-based samples are necessary to disentangle the impact of contextual factors on HRQOL. |
| Databáze: | MEDLINE |
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