| Autor: |
Johansson BE; Innovation Sciences, Armonk, NY 10504, USA. bertjoh@pol.net, Brett IC |
| Jazyk: |
angličtina |
| Zdroj: |
Vaccine [Vaccine] 2007 Apr 20; Vol. 25 (16), pp. 3062-5. Date of Electronic Publication: 2007 Jan 19. |
| DOI: |
10.1016/j.vaccine.2007.01.030 |
| Abstrakt: |
Current vaccination strategies against influenza rely on decades old technology of strain selection and prolonged labor-intensive, embryonated chicken-egg based production methods. Although, containing both major surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA), the immunity engendered by these vaccines is dominated by the anti-HA response. Consequently, current vaccines are susceptible to failure resulting from significant antigenic drift or shift in the time elapsing from the selection of the vaccine candidate strain and wild-type virus exposure. Therefore, immunity may be of short duration. There must be a change in vaccine strategy to include immunization with both HA and NA to broaden the immune response against influenza. Inclusion of the more slowly evolving NA in a vaccine against influenza will reduce the vulnerability to antigenic changes in a potential emerging influenza virus. Alternative production technologies such as recombinant baculovirus and yeast should be explored to decrease vaccine production times. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect