| Autor: |
Kraus D; Medical Microbiology and Hygiene Institute, University of Tübingen, Elfriede-Aulhorn-Strasse 6, 72076 Tübingen, Germany., Kalbacher H, Buschmann J, Berger-Bächi B, Götz F, Peschel A |
| Jazyk: |
angličtina |
| Zdroj: |
Infection and immunity [Infect Immun] 2007 Apr; Vol. 75 (4), pp. 2084-7. Date of Electronic Publication: 2007 Jan 29. |
| DOI: |
10.1128/IAI.01576-06 |
| Abstrakt: |
Peptidoglycan muropeptides, potent proinflammatory components, are amidated in Staphylococcus aureus for unknown reasons. To study whether this modification may modulate proinflammatory capacity, cytokine induction by isogenic S. aureus strains with different amidation levels and by synthetic amidated/nonamidated muramyldipeptides was evaluated. However, amidation did not significantly affect cytokine induction. This finding contributes to defining peptidoglycan receptor specificities and indicates that further rationales for muropeptide amidation have to be considered. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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