Hepatitis C virus acute quadriparetic vasculitic neuropathy responsive to cyclophosphamide.
| Autor: | Souayah N; New Jersey Medical School, Newark, NJ, USA. souayani@umdnj.edu, Sander HW, Menkes DL, Khella SL |
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| Jazyk: | angličtina |
| Zdroj: | Neurology, neurophysiology, and neuroscience [Neurol Neurophysiol Neurosci] 2006 Sep 18, pp. 5. Date of Electronic Publication: 2006 Sep 18. |
| Abstrakt: | Purpose: Hepatitis C viral [HCV] infection is a chronic multisystem disorder that may have an indolent course initially. Peripheral neuropathy associated with cryoglobulinemia and a systemic vasculitis is a well-described complication of HCV infection. But this neuropathy is not known to have a late-onset acute fulminant phase. This acute fulminant phase is characterized by quadriparesis associated with pulmonary and/or renal insufficiency, and it may occur despite adequate treatment for HCV infection. The purpose of this study is to report that patients treated for chronic HCV infection may manifest a secondary progressive acute fulminant neuropathy associated with respiratory and/or renal insufficiency that is responsive to cyclophosphamide. Methods: Case series retrospective data analysis. Results: Three patients with biopsy-proven HCV associated vasculitic neuropathy manifested a secondary progressive acute fulminant course resulting in quadriparesis within 5 years of the initial diagnosis. Complete remission was achieved with cyclophosphamide therapy such that all patients became ambulatory. Conclusions: HCV-associated vasculitic neuropathy may manifest a secondary phase, which is acute, fulminant and progressive that is superimposed on an otherwise slowly progressive disorder. Cyclophosphamide therapy may abort progression and induce remission of this acute fulminant phase. |
| Databáze: | MEDLINE |
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