| Autor: |
Gavrin LK; Department of Exploratory Medicinal Chemistry and Chemical Technologies, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, USA. gavrinl@wyeth.com, Lee A, Provencher BA, Massefski WW, Huhn SD, Ciszewski GM, Cole DC, McKew JC |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2007 Feb 02; Vol. 72 (3), pp. 1043-6. |
| DOI: |
10.1021/jo062120g |
| Abstrakt: |
This work describes two distinct routes to prepare pyrazolo[1,5-alpha]pyrimidin-7-ones and two distinct routes to prepare pyrazolo[1,5-alpha]pyrimidin-5-ones. Use of 1,3-dimethyluracil as the electrophile in the preparation of the pyrimidin-5-one regioisomer represents a correction of previously reported results. Also, a novel reaction to prepare this isomer was identified and the reaction mechanism elucidated. This work provides the experimentalist with complimentary synthetic pathways that afford either the pyrimidin-7-one or the pyrimidin-5-one regioisomer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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