| Autor: |
O'Byrne EM; CIBA-GEIGY Corporation, Research Department, Summit, NJ 07901., Goldberg RL, Doughty JR, Wong M, Blancuzzi V, Wilson D, Jeng AY |
| Jazyk: |
angličtina |
| Zdroj: |
Agents and actions [Agents Actions] 1991 Sep; Vol. 34 (1-2), pp. 232-4. |
| DOI: |
10.1007/BF01993289 |
| Abstrakt: |
The effect of SP on recombinant human IL-1 alpha-induced cartilage degradation in rabbit knees was investigated. Co-injection of 10 ng IL-1 and 1 micrograms SP did not increase cartilage degradation above the level observed after injection of 10 ng IL-1 alone. Co-injection of 100 ng IL-1 and 150 micrograms Spantide, a potent SP antagonist, did not reduce the level of cartilage degradation. Infusion of 100 ng SP/day for two weeks did not induce cartilage degradation. These observations suggest that cartilage degradation induced by IL-1 is independent of SP concentrations in rabbit knees. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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