Validation of intracranial area as a surrogate measure of intracranial volume when using clinical MRI.

Autor: Nandigam RN; Department of Neurology, Neurology Clinical Trials Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Chen YW, Gurol ME, Rosand J, Greenberg SM, Smith EE
Jazyk: angličtina
Zdroj: Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2007 Jan; Vol. 17 (1), pp. 74-7.
DOI: 10.1111/j.1552-6569.2006.00069.x
Abstrakt: Background and Purpose: We sought to determine whether mid-sagittal intracranial area (ICA) is a valid surrogate of intracranial volume (ICV) when using retrospective data with relatively thick (6-7 mm) sagittal slices.
Methods: Data were retrospectively analyzed from 47 subjects who had two MRI scans taken at least nine months apart. Twenty-three subjects had manual segmentation of ICV on the T2-weighted sequence for comparison.
Results: Intraclass correlation coefficient (ICC) for intraobserver, interobserver, and intraobserver scan-rescan comparisons were 0.96, 0.97 and 0.95. Pearson correlation coefficients between ICV and ICA, averaging the cumulative 1, 2, 3, and 4 most midline slices, were 0.89, 0.94, 0.93, and 0.95. There was a significant marginal increase in explained variance of ICV by measuring two, rather than one, slices (P= 0.001).
Conclusions: These data suggest that ICA, even measured without high-resolution imaging, is a reasonable substitute for ICV.
Databáze: MEDLINE
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