| Autor: |
Okokon JE; Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria. judeefiom@yahoo.com, Ubulom PM, Udokpoh AE |
| Jazyk: |
angličtina |
| Zdroj: |
Phytotherapy research : PTR [Phytother Res] 2007 Apr; Vol. 21 (4), pp. 366-8. |
| DOI: |
10.1002/ptr.2059 |
| Abstrakt: |
The antimalarial activity of an ethanol leaf extract of Setaria megaphylla was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections. Setaria megaphylla (100-300 mg/kg/day) exhibited a significant (p < 0.05) blood schizonticidal activity in 4-day early infection and in established infection with a significant (p < 0.05) mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. The leaf extract possesses a promising antiplasmodial activity in vivo which can be exploited in malaria therapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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