The oral mucosa in paucibacillary leprosy: a clinical and histopathological study.

Autor: de Abreu MA; Department of Dermatology, Division of Stomatology, Federal University of São Paulo, São Paulo, Brazil. lfmabreu@uol.com.br, Alchorne MM, Michalany NS, Weckx LL, Pimentel DR, Hirata CH
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [Oral Surg Oral Med Oral Pathol Oral Radiol Endod] 2007 May; Vol. 103 (5), pp. e48-52. Date of Electronic Publication: 2007 Jan 12.
DOI: 10.1016/j.tripleo.2006.10.002
Abstrakt: Background: Involvement of the oral mucosa can occur in lepromatous leprosy; however, lesions in the oral mucosa of paucibacillary patients have not been previously observed.
Objective: The objective of this study is to determine whether clinical and subclinical lesions exist in oral mucosa in nontreated paucibacillary leprosy patients, using clinical and histopathological examination.
Materials and Methods: A clinical and histopathological study involving 30 untreated paucibacillary leprosy patients was conducted. All patients underwent biopsies of the buccal mucosa, soft palate, and tongue. When acid-fast bacilli in association with inflammatory infiltrate, granulomatous or not, were encountered, it was considered "specific" involvement of the oral mucosa; and "nonspecific" involvement when the bacilli were not encountered.
Results: Eight nonspecific chronic inflammatory reactions and 1 granulomatous inflammatory process without acid-fast bacilli were detected.
Conclusions: Paucibacillary leprosy patients do not exhibit specific, clinical or subclinical, involvement in the oral mucosa; nonspecific alterations occur even in the absence of signs and symptoms.
Databáze: MEDLINE
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