[Insulin resistance and metabolic profile in lean and overweight/obese polycystic ovary syndrome patients].

Autor:	Kuba VM; Instituto Estadual de Diabetes e Endocrinologia, Rio de Janeiro, RJ. vmkuba@uol.com.br, Cavalieri PM, Christóforo AC, Faria Junior R, Caetano R, Coeli CM, Athayde A
Jazyk:	portugalština
Zdroj:	Arquivos brasileiros de endocrinologia e metabologia [Arq Bras Endocrinol Metabol] 2006 Dec; Vol. 50 (6), pp. 1026-33.
DOI:	10.1590/s0004-27302006000600008
Abstrakt:	Objective: To evaluate insulin sensitivity and the metabolic features in normal weight and overweight/obese patients with PCOS. Subjects and Methods: Forty-nine (49) patients from 18 to 45 years were retrospectively evaluated and divided into 2 groups, according to the body mass index (BMI): group 1 (18.5-24.9 kg/m(2)) and group 2 (25-40 kg/m(2)). Collected data: systolic and diastolic blood pressure; fasting and after OGTT glucose, insulin and glucose/insulin ratio; area under the curve for glucose and insulin; HOMA-IR and HOMA-beta; lipidic profile; free (FT) and total testosterone (T) levels. Results: Greater averages of pressoric levels, insulin resistance (IR) indices, triglycerides and the FT levels, in addition to lower HDL levels, were found in group 2. Neither correlation between the IMC with none of data nor of the FT and IR indices with the lipid profile were found. Conclusions: Obesity is associated with insulin resistance and diabetes mellitus in PCOS, independently on familiar history of DM. The absence of correlation between the IR indices and the FT with the lipidic profile suggests that other factors, such as the free fatty acids, can be involved in the pathogenesis of dyslipidemia in PCOS.
Databáze:	MEDLINE
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