| Autor: |
Chen AM; Merck & Co. Inc., PO Box 2000, Rahway, New Jersey 07065, USA. alex_chen2@merck.com, Ellison ME, Peresypkin A, Wenslow RM, Variankaval N, Savarin CG, Natishan TK, Mathre DJ, Dormer PG, Euler DH, Ball RG, Ye Z, Wang Y, Santos I |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2007 Jan 28 (4), pp. 419-21. Date of Electronic Publication: 2006 Nov 01. |
| DOI: |
10.1039/b612353h |
| Abstrakt: |
We report the first case of a pharmaceutical cocrystal formed between an inorganic acid and an active pharmaceutical ingredient (API), which enabled us to develop a stable crystalline and bioavailable solid dosage form for pharmaceutical development where otherwise only unstable amorphous free form or salts could have been used. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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