| Autor: |
El Sayegh TY; CIHR Group in Matrix Dynamics, University of Toronto, Room 243, Fitzgerald Building, 150 College Street, Toronto, Ont., Canada M5S 3E2. t.elsayegh@utoronto.ca, Kapus A, McCulloch CA |
| Jazyk: |
angličtina |
| Zdroj: |
FEBS letters [FEBS Lett] 2007 Jan 23; Vol. 581 (2), pp. 167-74. Date of Electronic Publication: 2007 Jan 03. |
| DOI: |
10.1016/j.febslet.2006.12.029 |
| Abstrakt: |
In fibrous connective tissues, fibroblasts are organized into syncytia, cellular networks that enable matrix remodeling and that are interconnected by intercellular adherens junctions (AJs). The AJs of fibroblasts are mediated by N-cadherin, a broadly expressed classical cadherin that is critically involved in developmental processes, wound healing and several diseases of mesenchymal tissues. In contrast to E-cadherin-dependent junctions of epithelia, the formation of AJs in fibrous connective tissues is relatively uncharacterized. Work over the last several years has documented an expanding list of molecules which function to regulate N-cadherin mediated junctions such as: Fer, PTP1B, cortactin, calcium, gelsolin, PIP5KIgamma, PIP2, and the Rho family of GTPases. We present an overview on the regulation of N-cadherin-mediated junction formation that highlights recent molecular advances in the field and rationalizes the roles of N-cadherin in connective tissue function. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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