| Autor: |
Prinzen L; Department of Biophysics, University of Maastricht, and Department of Radiology, University Hospital Maastricht, The Netherlands. L.Prinzen@bf.unimaas.nl, Miserus RJ, Dirksen A, Hackeng TM, Deckers N, Bitsch NJ, Megens RT, Douma K, Heemskerk JW, Kooi ME, Frederik PM, Slaaf DW, van Zandvoort MA, Reutelingsperger CP |
| Jazyk: |
angličtina |
| Zdroj: |
Nano letters [Nano Lett] 2007 Jan; Vol. 7 (1), pp. 93-100. |
| DOI: |
10.1021/nl062226r |
| Abstrakt: |
A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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