| Autor: |
Gravett MG; Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA. gravettm@u.washington.edu, Thomas A, Schneider KA, Reddy AP, Dasari S, Jacob T, Lu X, Rodland M, Pereira L, Sadowsky DW, Roberts CT Jr, Novy MJ, Nagalla SR |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of proteome research [J Proteome Res] 2007 Jan; Vol. 6 (1), pp. 89-96. |
| DOI: |
10.1021/pr060149v |
| Abstrakt: |
Intra-amniotic infection (IAI) is associated with preterm birth and perinatal mortality. To identify potential biomarkers, we performed a comprehensive survey of the cervical-vaginal fluid (CVF) proteome from a primate IAI model utilizing multidimensional protein identification technology (LC/LC-MS/MS) and MALDI-TOF-MS analyses. Analyses of CVF proteome identified 205 unique proteins and differential expression of 27 proteins in controls and IAI samples. Protein expression signatures and immunodetection of specific biomarkers identified can be employed for noninvasive detection of IAI. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
