Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling.
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| Grant Information: | P01 DK056116 United States DK NIDDK NIH HHS; R01 DK056731 United States DK NIDDK NIH HHS; DK56731 United States DK NIDDK NIH HHS; R01 DK062202 United States DK NIDDK NIH HHS; P51 RR000163 United States RR NCRR NIH HHS; DK53301 United States DK NIDDK NIH HHS; DK56116 United States DK NIDDK NIH HHS; R01 DK057768 United States DK NIDDK NIH HHS; R37 DK056731 United States DK NIDDK NIH HHS; RR0163 United States RR NCRR NIH HHS; R01 DK053301 United States DK NIDDK NIH HHS; DK57768 United States DK NIDDK NIH HHS; R37 DK053301 United States DK NIDDK NIH HHS; R56 DK062202 United States DK NIDDK NIH HHS; DK62202 United States DK NIDDK NIH HHS; K01 RR000163 United States RR NCRR NIH HHS |
| Substance Nomenclature: | 0 (Intracellular Signaling Peptides and Proteins) 0 (Neuropeptides) 0 (Orexins) 0 (Receptors, Cell Surface) 0 (Receptors, Leptin) 0 (STAT3 Transcription Factor) 0 (Stat3 protein, mouse) 0 (leptin receptor, mouse) |
| Entry Date(s): | Date Created: 20070105 Date Completed: 20070129 Latest Revision: 20220321 |
| Update Code: | 20240829 |
| PubMed Central ID: | PMC6672286 |
| DOI: | 10.1523/JNEUROSCI.3168-06.2007 |
| PMID: | 17202473 |
| Autor: | Münzberg H; Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA., Jobst EE, Bates SH, Jones J, Villanueva E, Leshan R, Björnholm M, Elmquist J, Sleeman M, Cowley MA, Myers MG Jr |
| Jazyk: | angličtina |
| Zdroj: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2007 Jan 03; Vol. 27 (1), pp. 69-74. |
| DOI: | 10.1523/JNEUROSCI.3168-06.2007 |
| Abstrakt: | Leptin directly suppresses the activity of orexigenic neurons in the hypothalamic arcuate nucleus (ARC). We examined c-Fos-like immunoreactivity (CFLIR) as a marker of ARC neuronal activity in db/db mice devoid of the signaling form of the leptin receptor (LRb) and s/s mice that express LRb(S1138) [which is defective for STAT3 (signal transducer and activator of transcription) signaling]. Both db/db and s/s animals are hyperphagic and obese. This analysis revealed that CFLIR in agouti related peptide-expressing orexigenic ARC neurons is basally elevated in db/db but not s/s mice. Consistent with these observations, electrophysiologic evaluation of a small number of neurons in s/s animals suggested that leptin appropriately suppresses the frequency of IPSCs on ARC proopiomelanocortin (POMC) neurons that are mediated by the release of GABA from orexigenic ARC neurons. CFLIR in POMC neurons of s/s mice was also increased compared with db/db animals. Thus, these data suggest that, although LRb-->STAT3 signaling is crucial for the regulation of feeding, it is not required for the acute or chronic regulation of orexigenic ARC neurons, and the activation of STAT3-mediated transcription by leptin is not required for the appropriate development of leptin responsiveness in these neurons. |
| Databáze: | MEDLINE |
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