| Autor: |
Kirkova M; Institute of Physiology, Bulgarian Academy of Sciences, 23 Acad. G. Bonchev St, 1113 Sofia, Bulgaria., Kesiova M, Konstantinova S, Alexandrova A, Petrov L, Tsvetanova E, Todorov S |
| Jazyk: |
angličtina |
| Zdroj: |
Autonomic & autacoid pharmacology [Auton Autacoid Pharmacol] 2007 Jan; Vol. 27 (1), pp. 63-70. |
| DOI: |
10.1111/j.1474-8673.2006.00390.x |
| Abstrakt: |
1. The in vivo effects of the non-steroid anti-inflammatory drug (NSAID) amtolmetin guacyl (AMG) on lipid peroxidation (LP) and on antioxidant enzyme and non-enzyme defence systems were investigated in models of stomach and colon damages, induced by other NSAIDs, by ethanol or by 2,4,6-trinitrobenzenesulfonic acid (TNBS). 2. Indomethacin increased LP, glutathione peroxidase (GSH-PX) and glucose-6-phosphate dehydrogenase (Glu-6-P-DH) activities and decreased glutathione levels in gastric mucosa. Pretreatment with AMG normalized some of the parameters affected by indomethacin. 3. Treatment of rats with ethanol for 0.5 h led to a decrease in glutathione levels as well as activities of glutathione reductase and Glu-6-P-DH in gastric mucosa. AMG, administered 0.5 h before ethanol, limited the adverse actions of ethanol. 4. Amtolmetin guacyl failed to abolish the TNBS-induced changes in the followed-up parameters in colon mucosa and liver, but additional alterations (as with tolmetin) were not observed. 5. The beneficial profile of AMG in the various experimental models of free radical-induced damage investigated in this study suggests the possibility that this drug might possess antioxidant activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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