| Autor: |
Poskitt DC; Commonwealth Serum Laboratories, Research and Development Division, Melbourne, Australia., Turnbull S, Macdonald L, Jean-François MJ, Yasmeen D |
| Jazyk: |
angličtina |
| Zdroj: |
International archives of allergy and applied immunology [Int Arch Allergy Appl Immunol] 1991; Vol. 95 (2-3), pp. 122-7. |
| DOI: |
10.1159/000235415 |
| Abstrakt: |
Mouse monoclonal (Ab1) anti-tetanus toxin/toxoid antibodies were used to raise Ab2 beta (tetanus toxin/toxoid internal image bearing) anti-idiotype antibodies in rabbits. Those rabbit serum antibodies (Ab2 beta) that did not bind to mouse serum proteins on an affinity column gave rise to an Ab3 anti-tetanus toxin/toxoid antibody response in mice. Rabbit serum antibodies that did bind to the affinity column, when eluted and used to inoculate mice also gave rise to an Ab3 anti-tetanus toxin/toxoid antibody response. It is suggested that one population of rabbit Ab2 beta anti-idiotype antibodies (unbound fraction) bears a partial or complete internal image of a tetanus epitope (Ab2 beta 1) while others (bound fraction) bear a complete or partial mirror image of a mouse immunoglobulin epitope as well (Ab2 beta 2). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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