| Autor: |
Benjamin E; Department of Anesthesiology, Mount Sinai Hospital, One Gustave L. Levy Pl., New York, NY 10029, USA., Paluch TA, Berger SR, Plawker M, Kaplan JA, Iberti TJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of cardiothoracic anesthesia [J Cardiothorac Anesth] 1987 Aug; Vol. 1 (4), pp. 309-12. |
| DOI: |
10.1016/s0888-6296(87)80043-1 |
| Abstrakt: |
Sinus tachycardia is a common complication of beta-adrenergic agonist therapy. A new selective bradycardic agent, N-allyl-clonidine, or alinidine, has been found effective against sinus tachycardia caused by a variety of stimuli. To determine whether it would also control catecholamine-induced sinus tachycardia, the effects of alinidine in two groups of anesthetized dogs treated with either dobutamine, 10 microg/ kg/min, or isoproterenol, 0.1 microg/kg/min, were studied. In both groups, alinidine significantly reduced the heart rate (P < .0001 in the dobutamine group, and P < .005 in the isoproterenol-infused dogs). The other hemodynamic effects of dobutamine were not adversely affected by alinidine, while the isoproterenol-infused dogs had a further afterload reduction when treated with alinidine. It is concluded that alinidine is effective against catecholamine-induced sinus tachycardia, possibly through mechanisms not related to beta-adrenergic receptors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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