Role of oncogenes in the regulation of MHC antigen expression.

Autor: Maudsley DJ; Department of Biological Sciences, University of Warwick, Coventry, U.K.
Jazyk: angličtina
Zdroj: Biochemical Society transactions [Biochem Soc Trans] 1991 Apr; Vol. 19 (2), pp. 291-6.
DOI: 10.1042/bst0190291
Abstrakt: Class I and class II major histocompatibility complex (MHC) antigens are required for CD8+ cytotoxic T cells and CD4+ helper T-cells, respectively, to recognize foreign antigen. Regulating the levels of expression of these MHC antigens regulates the T-cell responses [1]. This regulation is mainly carried out by the interferons (IFN), which are produced in the disease state. Type I IFN (IFN alpha or IFN beta; collectively 'IFN alpha beta) up-regulates class I MHC and IFN gamma up-regulates class I and class II MHC. We and others [1-3] have shown that transfection of cells with a variety of oncogenes including ras and myc affects the level of MHC antigen expression. This and other data provide evidence for a scheme in which the signal transduction mechanisms whereby IFN up-regulates MHC antigens involve several (proto) oncogenes.
Databáze: MEDLINE