Familial history of type 2 diabetes in patients from Southern Brazil and its influence on the clinical characteristics of this disease.

Autor:	Crispim D; Departamento de Genetica, Universidade Federal do Rio Grande do Sul., Canani LH, Gross JL, Tschiedel B, Souto KE, Roisenberg I
Jazyk:	angličtina
Zdroj:	Arquivos brasileiros de endocrinologia e metabologia [Arq Bras Endocrinol Metabol] 2006 Oct; Vol. 50 (5), pp. 862-8.
DOI:	10.1590/s0004-27302006000500006
Abstrakt:	Objective: To investigate the presence of maternal and paternal history of type 2 diabetes mellitus (DM) in relatives of 644 type 2 diabetic patients from Southern Brazil, and also to evaluate its influence on the clinical characteristics of this disease. Patients and Methods: Familial history of type 2 DM was investigated by a questionnaire. The maternal and paternal history was investigated over two generations. Complete data sets on familial history were obtained from 396 patients. Results: In general, 76.6% of the patients reported at least one first-degree affected relative. Besides, 31.6% of the patients reported a maternal history of type 2 DM and 12.6% reported a paternal history. Patients with maternal and/or paternal history presented a lower age at type 2 DM diagnosis when compared to patients without familial history. In addition, patients with only paternal history presented a higher frequency of hypertension than patients with no familial history. Conclusions: This study suggests that there is a significant maternal effect in the transmission of type 2 DM in Southern Brazil, and that most of the clinical characteristics of this disease do not differ between patients with or without familial history of type 2 DM.
Databáze:	MEDLINE
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