| Autor: |
Teixeira AR; Chagas Disease Multidisciplinary Research Laboratory, Faculty of Medicine, University of Brasília, PO Box 04536 70919-970, Federal District, Brazil. ateixeir@unb.br, Nitz N, Guimaro MC, Gomes C, Santos-Buch CA |
| Jazyk: |
angličtina |
| Zdroj: |
Postgraduate medical journal [Postgrad Med J] 2006 Dec; Vol. 82 (974), pp. 788-98. |
| DOI: |
10.1136/pgmj.2006.047357 |
| Abstrakt: |
Chagas disease is the clinical condition triggered by infection with the protozoan Trypanosoma cruzi. The infection is transmitted by triatomine insects while blood feeding on a human host. Field studies predict that one third of an estimated 18 million T cruzi-infected humans in Latin America will die of Chagas disease. Acute infections are usually asymptomatic, but the ensuing chronic T cruzi infections have been associated with high ratios of morbidity and mortality: Chagas heart disease leads to unexpected death in 37.5% of patients, 58% develop heart failure and die and megacolon or megaoesophagus has been associated with death in 4.5%. The pathogenesis of Chagas disease appears to be related to a parasite-induced mutation of the vertebrate genome. Currently, treatment is unsatisfactory. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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