| Autor: |
Galkin AN; Advanced Biomedical Researches Laboratory, Moscow 115446, Russia. Galkin_1@mail.ru, Gagarina EY, Lukyanova NS, Danilova TV |
| Jazyk: |
angličtina |
| Zdroj: |
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2006 Nov; Vol. 22 (11), pp. 1192-7. |
| DOI: |
10.1089/aid.2006.22.1192 |
| Abstrakt: |
We describe four full-length genomic sequences of HIV-1 subtype B isolates from Russia. These full-length HIV-1 genomes were amplified by nested polymerase chain reaction and sequenced. The sequences obtained were subjected to neighbor-joining phylogenetic analysis using a Kimura two-parameter model and to detailed sequence analysis. Comparison of the sequences obtained with 68 near full-length HIV-1 subtype B sequences from different geographic regions of the world revealed that isolates from Russia did not cluster significantly with other subtype B genomes. Sequences AY819715 and AY751407 significantly formed one cluster, which indicates their close similarity. The HIV-1 genomes obtained from Russia did not form a distinct homogeneous group inside subtype B. Their genetic diversity probably reflects the result of multiple introduction events of different subtype B strains to Russia. Sequences AY819715 and AY751406 possess some features of viruses from long-term survivors, such as specific extensions of the Env V2 region. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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