| Autor: |
Petrov SV, Raskin GA, Khasanov RSh, Tsyplakov DE |
| Jazyk: |
ruština |
| Zdroj: |
Arkhiv patologii [Arkh Patol] 2006 Sep-Oct; Vol. 68 (5), pp. 10-4. |
| Abstrakt: |
Overexpression of c-erbB2 oncogen is observed in 90-100% of cases of Paget's cancer. In all cases, the overexpression is caused by gene amplification. The authors carried out an immun ohistochemrical study of c-erbB2 (HER2/neu)-positive breast tumors: Paget's cancer (and hence with gene amplification) and breast invasive duct cancer without gene amplification. Moreover, the authors identified a case of c-erbB2-negative Paget's cancer, the phenotype of which was compared with the phenotypes of two earlier groups of tumors. The findings suggest that only formation of c-erbB2 heterodimers that cannot cause an increase in proliferation on their own is observed in the study groups of tumors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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