| Autor: |
Podlubnaia ZA, Podol'skiĭ IIa, Shpagina MD, Marsagishvili LG |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 2006 Sep-Oct; Vol. 51 (5), pp. 795-8. |
| Abstrakt: |
The anti-amyloidogenic capacity of hydrated fullerene C60 HyFn was revealed by the use of electron microscopy. We first showed that when, connecting with growing amyloid fibrils formed by A beta(25-35)-peptide, fullerene prevented their subsequent growth and interfered with the formation of new fibrils. Instead of long helically twisted ribbons formed by A beta(25-35)-peptide in the absence of fullerene, short narrow protofibrils were found in the presence of fullerene . These results allow one to suppose that fullerene can be useful for the therapy of Alzheimer's disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
